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Un Nouvel Essai Clinique sur la chloroquine qui promet

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Léquipe de l’infectiologue Marseillais, le Professeur Didier Raoult a publié ce 26 Mars 2020, les résultats d’un nouvel essai clinique qui promet. Cette fois-ci les essais ont été menés sur un échantillon de 80 personnes et à partir des résultats obtenus, le Professeur Raoult s’est permis d’affirmer que l’hydroxychloroquine, associée à un antibiotique, a été efficace. Cela n’empêche pas pourtant à certains médecins d’appeller à la prudence.

Nouvel Essai Clinique sur la Chloroquine

Ce nouvel essai clinique sur une formule combinée de la chloroquine et d’un antibiotique est l’un des cinq traitements qui sont testés actuellement dans le cadre de l’essai clinique européen Discovery qui a été lancé dans plusieurs pays pour tester quatre traitements, dont l’hydroxycholoroquine, sur 3 200 patients dont 800 cas graves en France. Les premiers résultats ne sont pas attendus avant deux semaines.

De 24 à 80 patients, le nouvel essai clinique du Pr. Raoult

Menée sur seulement 24 malades et suivant une méthodologie jugée contestable par certains, la première étude du professeur Raoult avait été vivement critiquée que ce soit par des collègues chercheurs ou par l’OMS. Le Professeur a donc dupliqué ses essais sur un nombre plus conséquent de patients atteints du Covid-19. Pour cela, il a effectué ses tests sur 80 malades admis aux urgences entre le 3 et le 21 mars. A ces patients, âgés de 18 à 88 ans, qui ont pris part au protocole, il a été administré du Plaquénil, un médicament à base d’hydroxychloroquine, associé à de l’azithromycine, qui a été l’antibiotique choisi.

Selon l’équipe du professeur Raoult, 78 de ces patients ont connu une « amélioration clinique » rapide de leur état de santé et ont pu quitter les soins intensifs au bout de cinq jours. Néanmoins, un patient, âgé de 86 ans, est décédé et un autre, de 74 ans, est toujours dans un état très grave. Le patient de 86 ans étant le seul ayant succombé à son infection au Coronavirus (covid-19)

Les résultats de ce nouvel essai sur la chloroquine connaissent des biais

Alors que 83 % des patients ayant reçu de l’hydroxychloroquine par les équipes du professeur Raoult ont connu une diminution de leur charge virale en l’espace d’une semaine et 93 % au bout de huit jours, ce protocole d’essai comporte néanmoins des biais. Ces résultats pourraient en effet s’expliquer par la guérison naturelle ou par une prise en charge dans de bonnes conditions sanitaires. Et ce, d’autant que certains des 80 malades sont jeunes (leur âgé médian est de 52 ans). Ils ont donc beaucoup moins de risques d’être dans un état grave, voire d’en mourir, selon les données portant sur l’ensemble des malades en France.

L’équipe médicale n’a par ailleurs pas utilisé de groupe témoin pour son étude, c’est-à-dire des patients qui ne sont pas soumis au même traitement. Ainsi, on ne peut pas assurer scientifiquement que les malades hospitalisés à Marseille et qui allaient mieux ont bénéficié du traitement qui leur a été donné ou d’autres facteurs. « Je serais ravi d’apprendre que ce traitement est efficace mais il faut que cela repose sur des arguments scientifiques car prescrire un médicament n’est jamais anodin, souligne le professeur Jean-Daniel Leliève, infectiologue à l’hôpital Henri-Mondor de Créteil. D’autant que ce médicament est potentiellement toxique sur le cœur chez des patients dont l’infection donne des atteintes cardiaques ».

Source Le Parisien
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